Abstract
The effects of saccharin on morphine-induced temperature change was examined in Long-Evans rats. Rats were given free access to 0.15% saccharin for 15 days, followed by saccharin deprivation for 9 days. Saccharin was then returned to one group, while a second group received water. All rats were then injected with morphine sulfate (2 mg/kg), and postinjection temperatures were assessed over 75 min. The results showed that saccharin enhanced the biphasic effects of morphine by significantly increasing the hypothermic phase. The findings support the view that sweet substances influence endogenous opioid release.
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