Abstract
rodentium. Results: During C. rodentium infection NK cells were recruited to both mucosal and systemic tissues where they expressed a diversity of immune-modulatory factors. In NK cell depleted mice we observed less severe colonic inflammation, which was associated with reduced immune cell recruitment and lower cytokine levels. However, bacterial loads were higher in NK cell depleted mice, and we also observed disseminated systemic infection, when compared to control infected mice. Interestingly, NK cells could also directly kill C. rodentium in vitro. Conclusion: Together these results suggest that NK cells protect the host from prolonged mucosal and systemic infection by contributing direct cytokine and antimicrobial cytotoxic factors, and by providing signals leading to the infiltration and increased activation of other crucial immune populations. This comprehensive anti-infection NK cell response may represent a promising therapeutic focus, particularly for approaches against enteric bacterial infections.
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