Abstract
symptoms. Overall fistula healing rates at wk 52 was 52%, and an analysis utilizing the last-observation-carried-forward showed no significant difference between the two groups at wk 52 in either complete cessation of drainage (MED 55% vs. COMBO 50% [p=0.83], Figure) or PDAI (MED 3 vs. COMBO 3.5 [p=0.86]). Time to cessation of drainage was also similar in both groups. Conclusion: There was no significant benefit to seton placement prior to starting anti-TNF therapy in terms of perianal fistula healing in CD. While setons should be used when clinically indicated, their routine use with an anti-TNF to facilitate fistula healing if large abscesses are absent was not supported by this study.
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