Abstract
Method: SAAD was a cross-sectional, observational study of depression in China, Korea, Malaysia, Singapore, Taiwan and Thailand. Participants were drug-free outpatients with depressed mood and/or anhedonia. Symptoms and clinical features were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS), Symptoms Checklist 90-Revised (SCL-90-R) and the Fatigue Severity Scale. Other measures included the Medical Outcome Survey 36-Item Short-Form Health Survey (SF-36), the Sheehan Disability Scale (SDS) and the Multidimensional Scale of Perceived Social Support (MSPSS). Based on the MADRS scores, participants were classified into mild, moderate and severe depression subgroups. Results: A total of 547 outpatients with major depressive disorder were included in the analyses. Among MADRS symptom scores, ‘reported sadness’ and ‘reduced sleep’ had the highest means (3.4 for both). The mean SCL-90-R obsession-compulsion subscale score was high (1.9). The mean SF-36 subscale score for ‘pain’ (58.4) was the second highest among the eight domains. In comparison to other SDS subscores, the mean ‘work/school’ subscores were highest in all three severity groups (ranging from 4.2 to 7.5). Compared to the moderate group, the severe group had significantly lower mean MSPSS total, ‘friends’ and ‘significant others’ dimension scores. Conclusions: This study suggests that pain has a minimal impact on quality of life in Asian patients with depression. Noteworthy issues in this population may include insomnia, obsessive-compulsive symptoms, working/school disability and family support. Acknowledgements: This study is the work of the MD-RAN (The Mood Disorders Research: Asian & Australian Network), which comprises the following members (in alphabetical order of family name [in capital letters]): Jae Nam BAE (Korea), Dianne BAUTISTA (Singapore), Edwin CHAN (Singapore), Sung-man CHANG (Korea), Chia-hui CHEN (Taiwan), CHUA Hong Choon (Singapore), Yiru FANG (China), Tom GEORGE (Australia), Ahmad HATIM (Malaysia), Yanling HE (China), Jin Pyo HONG (Korea), Hong Jin JEON (Korea), Augustus John RUSH (Singapore), Tianmei SI (China), Manit SRISURAPANONT (Thailand), Pichet UDOMRATN (Thailand) and Gang WANG (China). This study was supported by unrestricted research grants from Lundbeck A/S and the Duke-National University of Singapore Office of Clinical Research.
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