Abstract
G A A b st ra ct s CD, UC and HV were not significantly different and did not correlate with G0F/G2F ratio of IgG in both CD and UC. Serum MBL levels were negatively correlated with CDAI in patients with CD especially in G0F/G2F-positive CD patients. Although difference was not observed in terms of binding activity of agalactosyl IgGwithMBL compared to non-agalactosyl IgG, OVA was more effectively phagocytosed by THP-1 cells in the presence of agalactosyl IgG when compared with non-agalactosyl IgG. This phagocytic activity of agalactosyl IgG was competitively inhibited in the presence of mannan. Conclusions Agalactosyl form of IgG oligosaccharides did not associate with the activation of MBL-dependent lectin complement pathway. However, agalactosyl IgG enhanced antibody-dependent phagocytosis In Vitro. These findings suggest alterations of IgG oligosaccharides are not only a marker of IBD but also functionally modulate immune function of IBD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
