S1349 Impact of Chronic Nausea and Vomiting Syndrome on Work Productivity and Quality of Life: A Prospective Case-Control Study

Abstract

INTRODUCTION: Chronic nausea and vomiting syndrome (CNVS) is an uncommon functional nausea and vomiting disorder. It has been associated with several disorders of the brain-gut axis including irritable bowel syndrome and functional dyspepsia. The prevalence of functional nausea and vomiting disorders is 2.2% from which 50% are CNVS, affecting predominantly productive population. Mounting evidence has previously described a negative impact of CNVS on quality of life; however, the influence on work productivity it is reported in nausea and vomiting as isolated symptoms and not as part of CNVS. METHODS: A prospective case-control study was conducted to analyze socioeconomic and work productivity impact of CNVS on productive Mexican population. The research took place on Mexico during 2020. An internet survey was applied to 1000 active workers selected by random sampling. This study collected social, demographic and work related information; and analyzed psychological and digestive symptoms. Rome IV criteria for CNVS diagnosis, EQ-5D for evaluate quality of life (QOL) and Goldberg Scale for depression and anxiety. Comparisons with a logistic regression univariate and multivariate analysis with chi-squared test with 95% confidence intervals were calculated, as well as a comparative T-test. RESULTS: CNVS prevalence was 12.6%. Demographics were age of 30 ± 11 years with a predominance of female gender (66.3%). On CNVS, the mean age was (28 ± 9) with a predominance female gender (82.5%). Among employed with CNVS, 74% reported an impact on daily life versus 49% of those on the control group. Based on EQ-5D, pain-discomfort status was present on 48.4% and anxiety-depression status on 65%, 74.4% reported CNVS as a cause of presenteeism and 44.4% as a cause of annual absenteeism. Multiple logistic regression indicated that anxiety-depression overlap OR 2.104 (CI 95% 1.367-3.240, P = 0.001) and presenteeism OR 4.874 (CI 95% 2.784-8.536, P=< 0.001) were independently associated with CNVS, as well as male gender is a protective factor for developing CNVS OR 0.417 (CI 95% 0.248-0.699, P = 0.001). T-test indicated that CNVS patients have more per capital annual health spending and frequently sought medical attention (P=< 0.001). CONCLUSION: CNVS is more frequent on Hispanic population, affecting predominantly working age population. CNVS influences negatively in per capita annual health spending and work productivity being a common cause of absenteeism and presenteeism, as well as an independent factor for this last one.Table 1.: Multivariate analysis of associated factors to chronic nausea and vomiting syndromeTable 2.: T-Studen analysis of associated factors to chronic nausea and vomiting syndrome