Abstract
The aim of this study is to determine the S100B concentration in colostrums of 51 Burkinabe and 30 Sicilian women, still living in their countries, and in case of a difference to search for its explanations, considering also ethnic differences.The concentration of S100B, in colostrums of the first three days from the delivery, was assessed with commercial immunoluminometric assay.The production of colostrums was significantly higher in Burkinabe women, where the colostrums S100B levels in the first day of lactation showed to be at 24 h higher than those of Sicilian mothers (672.21 ± 256.67 ng/ml vs 309.36 ± 65.28 ng/ml) and progressively decreased reaching the values of Sicilian mothers in the second and third day (204.31 ± 63.25 ng/ml and 199.42 ± 45.28 ng/ml, respectively). Correlation was found between the level of S100B and the length of stage II (duration of expulsive phase of delivery), but the correlation with pain was found only in Burkinabe women.The S100B level in colostrums of Burkinabe mothers differs from that of Sicilians only in the first day of lactation, and in consideration that Burkinabe women produce more colostrums, their newborns receive, during the first days of life, an higher amount of S100B. The elevated quantity of S100B ingested by Burkinabe newborn in the first days of life could promote the physiological postnatal brain adaptation and maturation in the precarious delivery condition of African infants.
Highlights
Human milk contains a multitude of substances that guaranty the adaptation of newborns to the extra-uterine life, whose concentrations are regulated by a biological watch modulated by neuroendocrine and immune factors [1,2,3].S100B is an acidic vitamin D-dependent calcium-binding protein, involved in the regulation of all aspect of cell function, largely present in the nervous system, being highly concentrated in glial cells [4,5]
It could be the expression of white matter damage, involving for a more long time oligodendroglia differentiation, and the dosage of S100B became important in the monitoring and follow up of preterm with neurological damage [9]
We report the S100B levels in the colostrums of full term delivery Burkinabe and Sicilian women and our data show that S100B levels assessed in Burkinabe were significantly higher than those found in Sicilian colostrums only during the first day of lactation
Summary
S100B is an acidic vitamin D-dependent calcium-binding protein, involved in the regulation of all aspect of cell function, largely present in the nervous system, being highly concentrated in glial cells [4,5]. This protein has been isolated in different cells and biological fluids including the human milk [6]. Several reports underline the role of plasma S100B as a markers of neonatal asphyxia [9,10] It could be the expression of white matter damage, involving for a more long time oligodendroglia differentiation, and the dosage of S100B became important in the monitoring and follow up of preterm with neurological damage [9]
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