Rural settlements in geography: from antiquity to rural geography

The restructuring of social imaginations in rural geography

Cancers of unknown primary site: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Major research objectives

Repair of Tissues by Adult Stem/Progenitor Cells (MSCs): Controversies, Myths, and Changing Paradigms

Cultural Hybridity, Discordant Relationships, and Critical Perspectives

Commentary: Revascularization of the right ventricle-dependent coronary circulation: A paradigm change?

Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, compared with full-size antibodies, these antibody fragments lack the ability to bind the neonatal Fc receptor (FcRn) and have reduced half-lives. Fc engineered to bind antigens but preserve interactions with FcRn and Fc fused with monomeric proteins currently are being developed as candidate therapeutics with prolonged half-lives; in these and other cases, Fc is a dimer of two CH2-CH3 chains. To further reduce the size of Fc but preserve FcRn binding, we generated three human soluble monomeric IgG1 Fcs (mFcs) by using a combination of structure-based rational protein design combined with multiple screening strategies. These mFcs were highly soluble and retained binding to human FcRn comparable with that of Fc. These results provide direct experimental evidence that efficient binding to human FcRn does not require human Fc dimerization. The newly identified mFcs are promising for the development of mFc fusion proteins and for novel types of mFc-based therapeutic antibodies of small size and long half-lives.

Embedding Racial Justice and Advancing Health Equity at the American Medical Association

SummaryHeating battery at low temperatures is fundamental to avoiding the range anxiety and the time-consuming charging associated with electric vehicles (EVs). One method for achieving fast and uniform battery heating is to polarize the cell under pulse currents. However, the on-board implementation of this method leads to an increase in the cost and size. Therefore, in this study, an adapted EV circuitry compatible with the existing one and an optimized operating condition are proposed to enable rapid battery heating. With this circuit, electricity transfer between the cells can be realized through a motor, leading to remarkably higher battery currents than those of the conventional circuit. The increase in the maximum heating currents (from 1.41C to 4C) resulted in a battery temperature rise of 8.6°C/min at low temperatures. This heating method exhibits low cost, high efficiency, and negligible effects on battery degradation, practical and promising on battery heating of EVs.

IV Immunoglobulin for Asthma?

Disambiguating the bisphosphonates

Sustaining the Pediatric Endocrinology Workforce: Recommendations from the Pediatric Endocrine Society Workforce Task Force

Genetic Consequences of the Transatlantic Slave Trade in the Americas

In the first socialist systsem culture was more than a realm of artistry and aesthetics.1 It was often another dimension of a fierce struggle—ideological and political—against the bourgeoisie (Whit...

Delivering precision medicine in oncology today and in future—the promise and challenges of personalised cancer medicine: a position paper by the European Society for Medical Oncology (ESMO)