Abstract
SummaryObstruction of the pancreatic duct system in the rat and the guinea pig leads to the rupture of pancreatic acini and ductules, consistently demonstrable by the periodic acid‐Schiff (PAS) technique.In the rat with pancreaticobiliary obstruction ruptured acini and ducts can also be revealed by interposing an ink‐filled tube between the hepatic and common ducts.A study has been made of the time course of pancreatic histological changes following pancreatic duct obstruction in the rat with and without common‐channel biliary obstruction. The addition of common‐channel biliary obstruction only slightly modified the picture causing haemorrhage in the wall of the common duct and more frequent and severe fat necrosis in the first 18 hr.Preliminary studies in the dog suggest that the periodic acid‐Schiff (PAS) technique may be useful in detecting ruptured acini in that species also.The occurrence and significance of increased mucus concentration within the obstructed pancreatic duct system is discussed.
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