Abstract
The production of biologically inert rubber us. the production of biologically active sesquiterpene lactones is discussed in terms of the peculiar morphology and natural habitat of guayule (Parthenium argentatum). Selection for insect and microorganism resistance related to terpene (E-oligomers of isoprene) production may be antagonistic biochemically to selection for high rubber (Z-polyisoprene) content. Selection of resistant guayule crop strains, particularly through hybridization programs, is likely to introduce allergenic terpenes into the crop, since most Parthenium species produce sesquiterpene lactones similar to the dermatological compounds of P. hysterophorus, a serious health hazard in some places.
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