Abstract
OBJECTIVE: Gliomatosis cerebri (GC) is a diffusely infiltrating glial neoplasm of the brain. Radiotherapy for GC can be associated with improved survival, but the optimal therapy for GC is unclear. The aim of this study is to investigate the clinical result of GC after radiotherapy with/without chemotherapy and evaluate the recurrence pattern on focal radiation and whole brain radiation. PATIENTS AND METHODS: Between October 2006 and May 2015, 17 GC patients were diagnosed by MRI and biopsy. All patients received focal radiation to the tumor or whole brain radiation. Retrospectively, we reviewed 14 patients who were surveyed. RESULTS: Four patients received focal radiation and 10 patients received whole brain radiation. Mean progression free survival and overall survival in focal radiation group and whole brain radiation group were 17.3 and 16.8 months, respectively (p = 0.95). The recurrence without apparent anatomical relation to primary lesion had developed in 2 patients of focal radiation group and 3 patients of whole brain radiation group (p= 0.73). CONCLUSION: In the clinical outcomes of GC, there were no significant differences between focal radiation and whole brain radiation. Efficacy of chemotherapy is unclear in our series.
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