Abstract
BackgroundThe previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF). However, the distribution of this SNP differs significantly among various populations. The present study was to investigate whether combined evidence shows the association between ZFHX3 rs7193343 SNP and the risk of AF in various populations.MethodsA systematic search of all studies published through Dec 2014 was conducted using the Medline, Embase, WanFang, ScienceDirect, CNKI, and OVID databases. The case-control studies that evaluated an association between rs7193343 SNP and risk of AF were identified. The association between the ZFHX3 rs7193343 SNP and AF susceptibility was assessed using genetic models.ResultsWe collected 10 comparisons from six studies for rs7193343 SNP, including 1037 cases and 4310 controls in Asian, 5583 cases and 38215 controls in Caucasian, and then performed an updated meta-analysis and subgroup analysis based on ethnicity. In overall population, the occurrence of AF was found to be associated with T-allelic of rs7193343 SNP in ZFHX3 (OR =1.17, 95% CI 1.10-1.26). In subgroup analysis, we observed there was significant association between T-allele of rs7193343 and risk of AF in Caucasian subgroups (OR =1.20, 95% CI 1.12-1.30), but no statistically significance (OR = 1.07, 95% CI 0.92-1.24) in Asian population.ConclusionIn Caucasian population, genetic variant rs7193343 SNP is associated with risk of AF in Caucasian population. However, no association is found in Asian population based on the current evidence. Further studies with larger sample size involving case-control populations with multiple ethnics are still required in the future.
Highlights
The previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF)
Search strategy We performed a systematic search of Medline, Embase, WanFang, ScienceDirect, CNKI, and OVID to identify published epidemiological studies through Dec 2014 that were related to the rs7193343 ZFHX3 polymorphism and Atrial fibrillation (AF)
Search results We initially obtained 311 potential articles, and after screened abstract, among which most were excluded for no relevance to our analysis
Summary
The previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF). The present study was to investigate whether combined evidence shows the association between ZFHX3 rs7193343 SNP and the risk of AF in various populations. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice, and affect individuals suffer from increased rates of stroke, and lead to higher risk of incidence and mortality of cardiovascular disease [1]. The incidence of AF has estimated rate of 0.4–1.0 % which increases with age, in the general population [2, 3]. The factors that increase the risk of Recently, studies have provided unequivocal evidence that AF has the important relevance of genetic factors [7].
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