Abstract
Genetics is an important component in the development of coronary artery disease (CAD); however, studies on the Filipino population are lacking. This study aimed to determine the association of polymorphisms with the development of CAD among Filipinos. This is an ageand sex-matched case-control association study involving 122 adult Filipinos with CAD and 230 control participants without CAD. DNA from blood samples were genotyped for candidate single‐nucleotide polymorphisms (SNPs) using Illumina GoldenGate Genotyping (GGGT) assay. Candidate variants and clinical data were correlated with the occurrence of CAD using chi-square and logistic regression analysis. Of the candidate variants analyzed, only rs17465637 in MIA3 (adjusted OR 2.38; p = 0.024) was found to have a nominal association with the development of CAD among Filipinos after adjusting for hypertension, type 2 diabetes mellitus (T2DM), and smoking status. This finding may potentially allow earlier identification of Filipino patients at risk for CAD. Validation of these findings in a larger cohort is recommended.
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