Abstract
RP-HPLC was used to build sensitive and accurate procedures for establishing and verifying analytical methods for estimating levomilnacipran in bulk and pharmaceutical dose forms. The ratio of methanol to 10 mM dipotassium hydrogen phosphate buffer pH 6.5 in the mobile phase is 50:50 (v/v%). The working standard solution was 20 g/mL. With a flow rate of 1-mL/minutes, an injection volume of 20 μL, a run time of 10 minutes, and a detection wavelength of 215 nm, the analysis was carried out on XBridgeTM C18 column 5 (250 x 4.6 mm). Readings of the precision study %RSD were found to be below the 2% limit. With a r2 of 0.998, it was concluded that the strategy was linear. The results showed that the levomilnacipran LoD and LoQ values were 1.42 and 4.75 μg/mL, respectively. The approach may be used to analyse levomilnacipran bulk and pharmaceutical formulations.
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