Abstract
BackgroundSince the skin represents a common site of adverse drug reactions, few data are reported at this time regarding the development of skin rash during the treatment with antidiabetic drugs.Case presentationWe report a 29-year old woman that developed a facial skin rash during the treatment with metformin. Clinical and laboratory findings excluded the presence of systemic diseases, but several diagnosis and many drugs were administered without clinical improvement. The self-dismission of metformin induced an improvement of symptoms, while the re-challenge documented an impairments of skin rash. The Naranjo probability scale suggested a probable association between metformin and skin rash and metformin was definitively dismissed.ConclusionWe report for the first time a non vasculitis facial skin manifestation related to metformin in a young woman. However, this case may emphasizes the need to consider the ADRs as a differential diagnosis in order to reduce medical errors and the related medical costs.
Highlights
Since the skin represents a common site of adverse drug reactions, few data are reported at this time regarding the development of skin rash during the treatment with antidiabetic drugs.Case presentation: We report a 29-year old woman that developed a facial skin rash during the treatment with metformin
We report for the first time a non vasculitis facial skin manifestation related to metformin in a young woman
This case may emphasizes the need to consider the adverse drug reactions (ADRs) as a differential diagnosis in order to reduce medical errors and the related medical costs
Summary
We report for the first time a non vasculitis facial skin eruption during the treatment with metformin. We would remark that the diagnosis of ADR is not easy and often unreported and misdiagnosed [13,14]. This case may emphasizes the need to consider the ADRs as a differential diagnosis in order to reduce medical errors and the related medical costs. Consent Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. All authors read and approved the final version of manuscript
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