Abstract
Lymphoid malignancies are a heterogeneous group of neoplasms originating from B- and T-lymphocytes with an unexplained etiology. Several autoimmune conditions, especially Sjögren syndrome and rheumatoid arthritis (RA) are associated with lymphoma. Immunosuppressive agents like methotrexate may cause Epstein-Barr virus reactivation that can lead to development of lymphoma. The risk of lymphoma, especially Hodgkin lymphoma, is increased up to 2-3 times in RA patients compared to normal population. The cause of increased risk is independent from the immunosuppressive medication. We report here an unusual case of diffuse large B-cell lymphoma in a patient with RA receiving methotrexate treatment, after obtaining the approval of the informed consent of the patient.
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