Abstract
<p indent="0mm">In the human genome, more than 90% of the human genes undergo alternative splicing, which participates in the entire life activity. Abnormal RNA splicing is closely associated with human diseases, including cancer. Cancer is still a serious public health concern as the second leading cause of death. Every year, lung cancer ranks first in the number of new cancer cases and deaths. Abnormal alternative splicing occurs extensively in lung cancer, regulating tumorigenesis and lung cancer progression. Splicing factor mutations and aberrant expression are well-known drivers of lung cancer progression. Furthermore, alternative splicing plays a critical role in drug resistance, radiotherapy resistance, angiogenesis, and tumor metabolism.
Highlights
A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation Science Bulletin 66, 1342 (2021); Fast and furious: insights of back splicing regulation during nascent RNA synthesis SCIENCE CHINA Life Sciences 64, 1050 (2021); Distinct roles of alternative oxidase pathway during the greening process of etiolated algae SCIENCE CHINA Life Sciences 64, 816 (2021); A triple-combination nanotechnology platform based on multifunctional RNA hydrogel for lung cancer therapy SCIENCE CHINA Chemistry 63, 546 (2020); Inhibitory Effect of CT120B, an Alternative Splice Variant of CT120A, on Lung Cancer Cell Growth Acta Biochimica et Biophysica Sinica 37, 588 (2005); 中国科学: 生命科学
此外, 在脂 多糖(lipopolysaccharide, LPS)诱导的肺炎模型中, Slit2-WT/Slit2-Δ15的比值同样会减小, Slit2的表达被 抑制, 这提示Slit2-Δ15可能会促进炎症的发生
Summary
A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation Science Bulletin 66, 1342 (2021); Fast and furious: insights of back splicing regulation during nascent RNA synthesis SCIENCE CHINA Life Sciences 64, 1050 (2021); Distinct roles of alternative oxidase pathway during the greening process of etiolated algae SCIENCE CHINA Life Sciences 64, 816 (2021);. A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation Science Bulletin 66, 1342 (2021); Fast and furious: insights of back splicing regulation during nascent RNA synthesis SCIENCE CHINA Life Sciences 64, 1050 (2021); Distinct roles of alternative oxidase pathway during the greening process of etiolated algae SCIENCE CHINA Life Sciences 64, 816 (2021); A triple-combination nanotechnology platform based on multifunctional RNA hydrogel for lung cancer therapy SCIENCE CHINA Chemistry 63, 546 (2020); Inhibitory Effect of CT120B, an Alternative Splice Variant of CT120A, on Lung Cancer Cell Growth Acta Biochimica et Biophysica Sinica 37, 588 (2005); 中国科学: 生命科学 研究表明, 超过90%的人类基因会发生可变 剪接, 基因转录形成的前体RNA(pre-mRNA)经剪接可 形成不同的mRNA亚型, 这是形成蛋白质多样性的重 要来源之一[1~3]. RNA可变剪接发生在被称作剪接体的大型核糖 核蛋白(ribonucleoprotein, RNP)复合体中[4,5].
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