Role sialic acids in maintenance of an immune homeostasis

Abstract

The role sialic acids in maintenance of an immune homeostasis is considered. It is known, that sialic development both cleanly nonspecific protective effects, and specific, microbes agents providing interaction with specific receptors immunocompetent cells is peculiar to acids. Sialic acids represent components of cellular receptors, which are specific to viruses of family Adenoviridae, Reoviridae, Orthomyxoviridae and for many gram-positive bacteria. The facts reflecting the major role sialic of acids in maintenance of stability of a macroorganism to pathogenes of the various nature, and also in development of a somatic pathology and neoplatic processes are saved up. Concentration sialic acids also increases at sialydosis, a heart attack of a myocardium, oncological diseases, including at tumours of a brain. Especially high growth of this parameter is marked at the active form of a tuberculosis and rheumatism, at parenchymatous to a jaundice. After detachment from protein-carbohydrate complexes of fabrics free sialic acids inactivation many bacterial and virus agents. Therefore, the increase in the maintenance in blood sialoglycoproteines can be display compensatory, protective reaction of an organism. One of many reasons of formation immunology inconsistencies at ageing connect with reduction of concentration sialic acids in an organism. Sialic acids are capable is expressed to change process of recognition of tumoral antigens. The analysis of frequency expression different antigens on cells of various tumors in many cases can be used for an estimation of the forecast and a degree malignant tumoral process, and for reception of vaccines with the purpose immunotherapy.