Abstract
Plasma renin activity (PRA) was measured in rabbits by a modification of Picken's method. In the acute stage, PRA increased in 5 of 11 animals with unilateral constriction of renal artery but it did not increase in 13 of 15 animals with bilateral constriction of renal arteries. No clear correlation was found between PRA and blood pressure. In the chronic stage, PRA increased in 6 of 32 animals with unilateral constriction of renal artery. There were a positive correlation between PRA and blood pressure, and a negative correlation between PRA and serum potassium level. However, there were hypertensive animals without increase in PRA. Removal of the clipped kidney was followed by a fall of blood pressure in chronic hypertensive animals. The fall of blood pressure did not depend upon the previous level of PRA. These results suggest that the renin-angiotensin system does not play a primary role in the pathogenesis of experimental renal hypertension and unknown renal mechanism may be involved in it.
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