Abstract
Ovulation was never observed, even in the presence of gonadotrophins, when preovulatory follicles isolated from oestrous does were cultured in vitro (n = 112). If the follicles were co-cultured with pieces of ovarian tissue and gonadotrophins, then 50% ovulated (P less than 0.01). Attempts to replace the ovarian tissue by various steroid hormones or prostaglandins did not result in follicular rupture except when PGE-2 was used (23.8%, P less than 0.05). We suggest that gonadotrophins have an immediate (less than 1 h) action upon the follicle and ovarian interstitial tissue simultaneously. The response of the ovarian tissue to gonadotrophins is essential for eventual follicular rupture and involves PGE-2.
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