Abstract
Background: Acute ischemic stroke has been known to be a severely debilitating affliction with a steep disability and co morbidity curve. Various tools and methods have been attempted to ascertain if the diagnosis and prognosis of stroke can be achieved faster as it aids in effective management as well as reduces the resultant damage to the brain. Aim: The present study was designed to assess if serum D Dimer levels can be used as a marker as well as a volumetric determinant of stroke. Methods: The study involved a patient pool of 50 patients and corresponding controls who were matched for age and gender. The data collected included demographic data, baseline clinical parameters, serum D Dimer levels and a radiological assessment of the volume of infract. Findings: The study revealed that a relationship exists between the levels of circulating D Dimer and DW MRI weighted images showing infarcts. The relationship was direct in nature. Conclusion: D Dimer levels can provide a estimate of the area under infarction and thus prove to be a prognostic as well as diagnostic marker.
 Keywords: Acute ischaemic Stroke, D Dimer, Volumetric Association
Highlights
A by-product of fibrin degradation in thrombi is known as D -Dimer
(2) Studies have hypothesized that an elevated D Dimer level in systemic circulation can be a potential indication of increased coagulability of blood, clot formation or fibrin formations which can be further seen in symptoms/ conditions leading up to coronary heart disease
The present study showed that circulating D Dimer values are significantly elevated in case of acute ischemic stroke when compared with age and gender matched controls
Summary
A by-product of fibrin degradation in thrombi is known as D -Dimer. It is in use as a current marker for venous thromboembolism in suspected cases and has been clinically utilized as a marker in such scenarios due to its relative resistance to false positivity, a stable and detectable half-life and its persistence in clinically relevant conditions. [1] The values of circulating D Dimer is an indicator of the amount of fibrin degradation. [5,6,7,8,9,10] little or no research has been conducted in the sub population in Rural Maharashtra on efficacy of D Dimer and its resultant value in cases of Acute Ischemic Stroke. With this aim, a study was formed to find an association between levels of D Dimer and stroke volume and severity among patients of acute ischaemic stroke in Rural Maharashtra
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