Abstract
Perivascular adipose tissue surrounds most large blood vessels and plays an important role in vascular homeostasis. Recent studies have shown that perivascular adipose tissue effects vasodilation and vasoconstriction, which indicates that the perivascular adipose tissue regulates tone and diameter of the vessels. Adipocytokines and chemokines, secreted from the perivascular adipose tissue, apparently have direct access to the adjacent arterial wall by diffusion, or through vasa vasorum . The present data indicate that perivascular adipose tissue plays an important role in atherosclerosis, hypertension. Recently, some studies were performed that examined the role of perivascular adipose tissue in non-atherosclerotic vascular diseases, such as neointimal formation, aortic aneurysm, arterial stiffness and vasculitis. The present review will discuss a role of perivascular adipose tissue in pathogenesis of atherosclerosis, hypertension and non-atherosclerotic vascular diseases.
Highlights
Медицинская Иммунология Medical Immunology (Russia)/Meditsinskaya Immunologiya to the adjacent arterial wall by diffusion, or through vasa vasorum
The present data indicate that perivascular adipose tissue plays an important role in atherosclerosis, hypertension
Some studies were performed that examined the role of perivascular adipose tissue in non-atherosclerotic vascular diseases, such as neointimal formation, aortic aneurysm, arterial stiffness and vasculitis
Summary
Медицинская Иммунология Medical Immunology (Russia)/Meditsinskaya Immunologiya to the adjacent arterial wall by diffusion, or through vasa vasorum. For citation: E.G. Uchasova, O.V. Gruzdeva, Yu.A. Dyleva, E.V. Belik “Role of perivascular adipose tissue in the development of atherosclerotic and non-atherosclerotic diseases”, Medical Immunology (Russia)/Meditsinskaya Immunologiya, 2019, Vol 21, no. Установленные данные также свидетельствуют о том, что дисфункциональный ПВЖТ играет важную роль в развитии атеросклероза и гипертонии, путем частичного повышения инсулинорезистентности [14].
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