Abstract
SummaryPericytes are morphologically, biochemically, and physiologically heterogeneous and play an essential role in angiogenesis. Pericytes interact with endothelial cells, stabilize the newly formed endothelial tubes, modulate blood flow and vascular permeability, and regulate endothelial proliferation, differentiation, migration and survival. This chapter will review the biology, physiology and pathology of pericytes, as well as their role in angiogenesis. We will also discuss the potential relevance of pericytes in anti-angiogenic therapeutic approaches. Dual targeting of both endothelial and pericytes may provide more efficacious anti-angiogenic approaches for cancer therapy.
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