Abstract
The effect of neutropenia, induced by anti-neutrophil serum, on hyperbaric and normobaric oxygen toxicity was examined in rats. The myeloperoxidase (MPO) assay was used to quantitate the accumulation of neutrophils in lung tissues. It was found that anti-neutrophil serum decreased lung MPO content dramatically. However, such neutropenia did not protect rats against hyperbaric, nor normobaric, oxygen toxicity. Lung MPO activity increased in rats and mice exposed to normobaric hyperoxia for 60 and 70 h whereas lung MPO contents in rats and mice was unaltered immediately following hyperbaric oxygen exposure. However, lung MPO gradually increased in lungs of rats exposed to hyperbaric oxygen for 30 min and then sacrificed after 1, 6 or 24 h in room air. Our results confirm that neutrophil accumulation is not a precursor to lung injury, but occurs as a secondary effect representing a nonspecific reaction to hyperoxic lung injury.
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