Abstract
Neurofilament light chain (NfL) is a main element of neurons’ structure which is exclusively confined to the neuroaxonal compartment, NfL therefore provides an advantage over other potential biomarkers since it’s highly selective for neuronal cell injury and eventual neuronal cell death. Independent of etiology, NfL levels in CSF and blood increase above normal in response to neuronal damage and neurodegeneration, making it a suitable candidate as a biomarker in these circumstances. Biomarkers of neuronal injury and neurodegeneration have the potential to enhance diagnostic accuracy, disease monitoring, and prognosis.
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