Abstract
Correlative morphological and physiological analysis was made in order to clarify the role of microtubules in secretory activity in the rat anterior pituitary cells in vivo. Immunofluorescence microscopy showed a relatively intense tubulin staining in all secretory cells, although the staining intensity varied among different cell types. By thin-section electron microscopy, microtubules were distributed preferentially in perinuclear regions. They radiated from Golgi areas toward the cell periphery, and were closely associated with secretory granules and mitochondria. Microtubules were more abundant in ACTH-, and some of prolactin (PRL-) and TSH-cells than in other types of cells.
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