Abstract
Mdm2 is a well known oncogene which affects expression of various genetic factors. It encoded oncoprotein Mdm2 of 491 amino acids divided into four major domains (p53-binding, acidic, Zn-finger and ring finger). Acting as an E3-ubiquitin ligase, Mdm2 induced degradation of various proteins which affect the cellular transformation such as p53, p73, JMY, FOXO3a, HPIP, HDAC, p21Waf1/CIP1 etc. Thus, Mdm2 found to be responsible for up and down regulation proteins in cellular system and plays crucial role in several human cancers through variety of biological pathways. Here, we described the major classes of human cancers in which Mdm2 involved directly or indirectly. Moreover, mechanistic role of Mdm2 summarised along with intermediates of cellular biochemical pathways regulated or expressed by it.
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