ROLE OF MACROPHAGES IN IMMUNOPATHOGENESIS OF PSORIASIS AND OBESITY

Abstract

Psoriasis is one of the most common chronic recurrent multifactorial diseases of the skin with a predominance of genetic factor. The disease is characterized by hyperproliferation of epidermal cells, impairment in the keratinisation process against inflammatory reactions in the dermis, and by lesions on the nails, joints and scalp. According to the results of clinical and epidemiological research, about 3-4% of the population of our planet has psoriasis, regardless of gender, age and ethnic group, while the share of this pathology in the overall structure of skin diseases reaches from 1% - to 40% [4, 5], according to various data. However, despite the widespread of psoriasis and the large number of works on this problem, there is still no unified view on the pathogenesis of this dermatosis. To clear up the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidities typically associated with this pathology. Recently, there has been a tendency towards the growth of psoriatic disease and obesity in the pathogenesis of which a significant role is assigned to systemic inflammation and macrophages. According to the results of this research, it has been found out that obesity and psoriasis has a common link of the pathogenesis, systemic inflammation, which manifests itself in the increased number of macrophages producing a large number of proinflammatory cytokines. Thus, obesity and inflammation causes a vicious circle of cause-and-effect relationships. Obesity provokes inflammation, and inflammation, in turn, increases obesity and prevents weight loss. The close relationship between psoriasis and obesity is extremely important in selecting patient-centred therapy. Therefore, the goal of further research is to carry out detailed study of the psoriatic comorbidities that will contribute into revealing new targets for the treatment of this dermatosis.