Abstract
Objective:To compare the clinicopathologic features of patients with endometrial cancer (EC) with recurrent disease with a primary surgery, stage, grade, and tumor histotype-matched cohort of patients without recurrence.Materials and Methods:Patients with EC who were surgically treated at a single tertiary care institution between 2005 and 2015 were enrolled in this study. The dataset included 381 consecutive patients with EC, of which 31 (8.1%) had disease recurrence. Data consisting of age at surgery, CA- 125 concentration at diagnosis, number of lymph nodes harvested, growth pattern of the primary tumor, location of the primary tumor within the endometrium, tumor histotype, tumor grade, disease stage, adjuvant therapy, disease recurrence, time to recurrence, CA-125 concentration at recurrence, clinical and imaging findings at recurrence, and treatment modalities used for recurrent disease were extracted from the institutional database.Results:After 1-to-1 propensity-score matching of patients with and without recurrence, the clinicopathologic features of 26 patients from each group were compared. Patients with recurrent disease were found to have a significantly higher CA-125 concentration at initial diagnosis (p<0.001) and different tumor growth pattern (p=0.019) than patients without disease recurrence. The papillary growth pattern of the primary tumor was significantly associated with disease recurrence as compared with polypoid and infiltrative patterns. Omental involvement, papillary tumor growth, and advanced age were associated with increased mortality.Conclusion:Our results indicated that higher CA-125 concentrations at initial diagnosis and papillary growth pattern of primary tumors were found to be associated with disease recurrence.
Highlights
Endometrial cancer (EC) is the most common cancer of the female genitourinary system in the United States of America and the 4th most common tumor in Western countries, with more than 280.000 patients appearing yearly, globally[1]
Data consisting of age at surgery, CA125 concentration at diagnosis, number of lymph nodes harvested, growth pattern of the primary tumor, location of the primary tumor within the endometrium, tumor histotype, tumor grade, disease stage, adjuvant therapy, disease recurrence, time to recurrence, CA-125 concentration at recurrence, clinical and imaging findings at recurrence, and treatment modalities used for recurrent disease were extracted from the institutional database
The papillary growth pattern of the primary tumor was significantly associated with disease recurrence as compared with polypoid and infiltrative patterns
Summary
Endometrial cancer (EC) is the most common cancer of the female genitourinary system in the United States of America and the 4th most common tumor in Western countries, with more than 280.000 patients appearing yearly, globally[1]. Numerous features have been examined to evaluate their effect on recurrence; patient’s age at diagnosis, the stage, histologic type, cell type, cervical involvement, depth of myometrial invasion, and lymph node metastasis at the time of treatment were identified as the most significant prognostic factors in patients with EC[7,8]. These factors are not satisfactory to precisely predict the prognosis of these patients. To examine the roles of less commonly agreed risk factors on disease recurrence, we compared the clinicopathologic features of patients with recurrent disease with a primary surgery, stage, grade,and tumor histotypematched cohort of patients without recurrence
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
