Abstract
We eluciated whether K + channels modulate adrenal catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP) in the isolated perfused rat adrenal gland. PACAP (100 nM) increased adrenal epinephrine output. The PACAP-induced responses were enhanced by treatment with apamin (10–100 nM) in a concentration-dependent manner. In the presence of nifedipine (3 μM), apamin (1 μM) did not enhance the PACAP-induced responses. Charybdotoxin (1–100 nM) had little influence on the PACAP-induced responses. These results suggest that small-conductance Ca 2+-activated K + channels interfere with L-type voltage-dependent Ca 2+ channels to counteract the PACAP-induced adrenal catecholamine secretion.
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