Role of Inflammatory Markers in Patients with Coronary Artery Ectasia versus Patients with Obstructive Coronary Artery Disease

Abstract

Abstract Objective: The aim of the study is to compare between Eosinophilic Count (EC), Mean Platelet Volume, (MPV), Neutrophil/Lymphocyte Neutrophil Ratio (NLR) and High Sensitive CRP (HS-CRP) level in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Methods: 150 patients underwent diagnostic coronary angiography in cardiology departments of Mahalla cardiology center and Benha University hospitals, divided into three groups, 50 patients with Coronary Artery Ectasia (CAE), 50 patients with Obstructive Coronary Artery Disease (O-CAD) and 50 patients as a control group. <span style=font-size:10.0pt;line-height:150%; font-family:Arial,sans-serif;color:#636363>Results: All parameters were found to be significantly increased when comparing patients have CAE or O-CAD with the controls (P<0.001). Plasma levels of EC and HS-CRP were significantly higher in CAE patients compared with O-CAD patients (0.202 ± 0.075, 0.126 ± 0.031/nl, P<0.001), (2.45 ± 0.5, 2.23 ± 0.42 mg/l, P=0.045) respectively. Meanwhile levels of MPV and NLR were insignificant in CAE patients compared to O-CAD patients (7.354 ± 0.623, 7.338 ± 0.486 fL, P=0.642), (2.857 ± 0.88, 2.667 ± 0.569, P=0.222) respectively. Conclusion: This study has revealed a relationship between plasma EC and HS-CRP and Coronary Artery Ectasia (CAE) in comparison to patients with Obstructive Coronary Artery Disease (O-CAD). These results confirm that CAE is a more severe inflammatory process than O-CAD. Keywords: Angiography; Coronary Ectasia; Eosinophils; High Sensitive CRP; Inflammatory Markers <span style=font-size:10.0pt;line-height:150%; font-family:Arial,sans-serif;color:#636363> Abbreviations: AUROC: Area Under Receiver Operating Characteristic curve; CAD: Coronary Artery Disease; CAE: Coronary Artery Ectasia; CI: Confidence Interval; EC: Eosinophilic Count; HS-CRP: High Sensitive CRP; MPV: Mean Platelet Volume; NLR: Neutrophil/Lymphocyte Neutrophil Ratio; NPV: Negative Predictive Value; OR: Odds Ratio; O-CAD: Obstructive Coronary Artery Disease; PPV: Positive Predictive Value; ROC curve: Receiver Operating Characteristic curve; SN : Sensitivity; SP: Specificity <span style=font-size:10.0pt;line-height:150%;font-family:Arial,sans-serif; color:#636363>