Abstract
AimsModulation of vasodilating actions by quercetin, a kind of flavonoid, was investigated using rat mesenteric arterial ring strips. Main methodsRing strips (1mm) of rat mesenteric artery were used. The specimens were kept at 36.5°C in Krebs–Henseleit solution oxygenated with 95% O2 and 5% CO2. Key findingsQuercetin (0.1 to 100μM) dilated the contraction induced by norepinephrine (1μM) in a concentration-dependent manner. The quercetin-induced vasodilatation was almost resistant to both 100μM L-NG-nitro arginine methyl ester (L-NAME) and 100μM indomethacin. At 1mM tetraethylammonium (a KCa channel inhibitor) decreased the quercetin-induced vasodilatation, which was resistant to L-NAME and indomethacin, but not significantly. L-NAME- and indomethacin-resistant quercetin-induced vasodilatation was significantly attenuated by 100μM 18α- and 50μM 18β-glycyrrhetinic acids (gap junction inhibitors). Endothelium removal as well significantly attenuated the vasodilatation to the same extent. SignificanceThese results indicate that quercetin dilates the mesenteric artery via endothelium-dependent mechanisms, and the dilatation is mainly mediated by gap junctions closely involved with endothelium-derived hyperpolarizing factor (EDHF).
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