Abstract
We investigated GABA receptor subtypes mediating GABA-induced inhibition of red nucleus (RN) neuronal firing recorded extracellularly from anaesthetized rats. GABA response was mimicked by the GABA A agonists muscimol and isoguvacine in all cases and was partially blocked by the GABA A antagonist bicuculline. The GABA B agonist baclofen induced a long-lasting inhibition in 84% of cells. Neurons responding to either GABA A or GABA B agonists were equally distributed within the RN. The GABA C receptor agonist cis-amino-crotonic acid (CACA) did not modify RN neuronal firing; at high doses CACA occasionally induced inhibition abolished by bicuculline and thus mediated by GABA A receptors. We conclude that the inhibitory effects of GABA in the RN are mediated by both GABA A and GABA B receptors, whereas GABA C receptors are not involved.
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