Abstract
Water-deprived rats learned in one trial to avoid fluids whose tastes were paired with an intraperitoneal injection of a potent hashish extract. Aversions of similar strength were conditioned to different novel tastes on successive pairing sessions in the same animals, suggesting that the aversive effects of the drug are not a function solely of the novelty of the drugged state. Pretreatment with an inhibitor of drug-metabolizing hepatic enzyme systems greatly reduced the strength of hashish-induced learned taste aversions; thus the metabolites of cannabis underlie its noxious effects on the molecular level.
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