Abstract
The goal of the study was analysis of the role of novel serotonin-modulating anticonsolidation protein (SMAP; Mekhtiev, 2000) being in linear relationship with serotonin level and, perhaps, realizing its functions on subcellular level, in formation of seizure activity in rabbits. To achieve this goal SMAP blockade in the brain structures was realized with rabbit anti-SMAP polyclonal antibodies or autoantibodies produced in the organism of experimental animals as a result of immunization with SMAP. The results indicate to an important role of maintaining optimal level of serotonergic system’s activity in prevention of development of seizure activity as well as that down regulation of this system in the organism might timely inform about possible forthcoming advent of epilepsy fits.
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