Abstract
Metabolism in vitro and in vivo of aniline and aminopyrine metabolism in vitro were significantly reduced in magnesium-deficient rats. Magnesium depletion did not alter the rate of metabolism in vitro of p-nitrobenzoic acid or pentobarbital, nor the duration of action of pentobarbital. Microsomal protein and RNA levels were maintained during magnesium depletion, but a significant decrease in the cytochrome P-450 content of the microsomes was noted in magnesium-deficient rats at approximately the same time as the lower rate of drug metabolism was noted. Hepatic enzyme activities and P-450 levels were restored to normal by feeding magnesium-deficient rats a magnesium-containing diet for 8 days. The results indicate that the impairment of hepatic drug metabolism in magnesium deficiency results from a decrease in the specific activity of the microsomal enzymes or from an alteration in the cytochrome P-450 levels.
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