Abstract
ABSTRACT Alcohol is a neurotoxin associated with significant mortality and morbidity. Ethanol is found to induce a dose-dependent increase in lipid peroxidation. The elevation in lipid peroxidative products and the loss of antioxidant defense potential are enhanced when alcohol is consumed along with polyunsaturated fatty acids. The present study evaluated the effect of Cuminum cyminum on lipid peroxidation induced by ethanol and preheated (to oxidize) sunflower oil. Hepatotoxicity, assessed by the activities of plasma aspartate transaminase (AST), alkaline phosphatase (ALP), and γ-glutamyl transferase (GGT), was apparent in rats fed alcohol and preheated oil as compared with control rats on a normal diet. The toxicity was associated with lipid peroxidation and a disruption in the antioxidant defense mechanism, as evidenced by increased levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides, and free fatty acids (FFA) in the liver; decreased levels of glutathione, vitamin C, and vitamin E in the liver and kidney; and decreased activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in the liver. Treatment with cumin significantly reversed the metabolic trends associated with alcohol and preheated sunflower oil, bringing liver and kidney activities close to normal levels, indicating antioxidant properties of cumin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
