Abstract
Now, the biomarker for bone metabolism have important role on treatment of osteoporosis. It is important to develop the reliable biomarker to detect the early stage of osteoarthritis. The biomarker could be useful tool not only to study what exercise is good for the treatment and prevention of progression of osteoarthritis but also to develop new drug therapy. We focused on role of cleavage of type II collagen by collagenase in osteoarthritis with immunoassay for the specific cleavage site.
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