Abstract
A prominent feature of respiratory neural activity is the abrupt change of discharge at the phase transitions (IOS, inspiratory off-switch; EOS, expiratory off-switch). The observation of this nonlinearity has led to the search for specialized populations of brainstem neurons which change their activity immediately preceding a phase-switch. In this laboratory, we have used the method of producing perturbations of the respiratory cycle by means of phase-linked inputs and then comparing the temporal changes in the output (phrenic discharge) and in firing of different types of brainstem respiratory neurons. We here report the use of vagal (V) afferent inputs to study such responses.
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