Abstract
ADP ribosylation factors (ARFs), a family of small GTPases, play an important role in membrane trafficking and actin cytoskeletal rearrangement. For the activation of ARFs, the exchange of GDP for GTP that is catalyzed by guanine nucleotide exchange factors (GEFs) is necessary. We previously identified a novel guanine nucleotide exchange protein (GEP) for ARF with a molecular size of ∼100-kDa (ARF-GEP100, GEP100), which preferentially activates ARF6. Our current work has focused on investigating the role of GEP100 in leukocytes. In the present study we report findings suggesting that GEP100 is involved in the Fc and complement receptor-mediated phagocytosis in human macrophage-like differentiated human U937 cells, through RNAi knockdown experiments on GEP100.Here, we briefly review ARFs and ARF-GEFs, and introduce a novel GEP100 function, namely the involvement of phagocytosis in monocyte/macrophage-like cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
