Abstract
The recent discovery of a G protein homolog involved in a yeast signal transduction system indicates that G proteins are conserved over a wide evolutionary distance (Dietzel and Kurjan, 1987; Nakafuku et al., 1987; Miyajima et al., 1987; Jahng et al., 1988). The extensive genetic characterization possible in yeast allows a type of approach to the study of G proteins not possible in vertebrate systems. Using such a genetic approach, we isolated theSCG1 gene, which encodes a homolog to the a subunits of G proteins. Genetic results have also provided evidence thatSCG1 is involved in pheromone response in yeast. Recently, putative homologs to the vertebrate s and γ subunits have also been identified (M. Whiteway, personal communication). In this paper, after presenting background information on pheromone response, I will describe the isolation and characterization ofSCG1 and will discuss our currently favored model of the mechanism of action ofSCG1 in the pheromone response pathway.
Published Version
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