Abstract
It remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). Therefore, we enrolled 109,360 patients with peptic ulcer disease and matched for age and sex with 218,720 controls from the Taiwan National Health Insurance Research Database between January 1, 1997 and December 31, 2013.The HNC incidence rate was 1.33-fold higher in the peptic ulcer group than in the control group (7.52 vs. 5.68 per 100,00 person-years; crude relative risk: 1.33; 95% confidence interval [CI]: 1.08–1.63) after > 6 years of follow-up. However, in the peptic ulcer subgroup with H. pylori treatment, HNC risk was not significantly different from that of the control group (crude relative risk: 1.12; 95% CI: 0.86–1.46). Moreover, the population with peptic ulcers had the highest risk of laryngeal and hypopharyngeal cancer (adjusted HR: 2.27 [95% CI: 1.16–4.44] and 2.00 [95% CI, 1.13–3.55]), respectively. This observational study suggested that peptic ulcer disease is associated with an increased incidence of laryngeal and hypopharyngeal cancer and H. pylori treatment may have a role in preventing HNC in patients with peptic ulcer disease.
Highlights
It remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC)
The incidence rate was higher in the total peptic ulcer group, no significant difference was observed between the groups; the crude relative risk was 1.11 (95% confidence interval [CI]: 0.99–1.25)
The results revealed that the population with untreated peptic ulcer has a higher risk of HNC comparing with control group in different age, sex or hospitalization at baseline subgroups (Table 4)
Summary
It remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). The population with peptic ulcers had the highest risk of laryngeal and hypopharyngeal cancer (adjusted HR: 2.27 [95% CI: 1.16–4.44] and 2.00 [95% CI, 1.13–3.55]), respectively This observational study suggested that peptic ulcer disease is associated with an increased incidence of laryngeal and hypopharyngeal cancer and H. pylori treatment may have a role in preventing HNC in patients with peptic ulcer disease. No study has discussed whether H. pylori treatment can reduce the incidence of head and neck cancer (HNC). To address the aforementioned research gap, this nationwide population base cohort study investigated (1) whether peptic ulcer disease is a risk factor for HNC and (2) whether H. pylori treatment can reduce the risk of HNC in patients with peptic ulcer disease
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