Abstract
Objective: To study the risk factors for recurrent ectopic pregnancy (REP) in patients undergoing in vitro fertilization (IVF).Methods: This was a 1:4 matched case-control study that enrolled 227 REP patients and 908 matched intrauterine pregnancy (IUP) patients from the assisted reproductive technology (ART) center of the First Affiliated Hospital of Zhengzhou University from January 2012 to November 2019. Univariate analysis was carried out between the two groups for the occurrence of REP. Multivariate logistic regression analysis was used to explore the risk factors of REP after IVF.Results: The results of univariate analysis showed that there were significant differences in previous treatment of EP, stage of embryo and the number of embryos transferred between the two groups (all P < 0.05). The other factors did not have a significant effect on the probability of developing REP. Multivariate logistic regression analysis showed that after adjusting for confounders, previous treatment of EP, type of embryos transferred and stage of embryo were related to the occurrence of REP (all P < 0.05).Conclusion: Conservative treatment, frozen-thawed embryo transfer and cleavage embryo transfer were independent risk factors for REP after ART treatment.
Highlights
Ectopic pregnancy (EP) accounts for ∼2% of all pregnancies
With the wide application of assisted reproductive technology (ART) in the field of reproduction, it is of great clinical value to identify the risk factors of recurrent ectopic pregnancy (REP) in infertile patients with a history of EP
If women at risk can be identified in the early stages of ART and Recurrent Ectopic Pregnancy Risk Factors be provided with targeted treatment to protect their reproductive ability, they may be able to avoid another occurrence of REP
Summary
Ectopic pregnancy (EP) accounts for ∼2% of all pregnancies It is a common life-threatening emergency and an important cause of maternal morbidity and mortality, as well as fetal loss [1,2,3]. As a long-term complication of EP, recurrent ectopic pregnancy (REP) is increasing [5], which has seriously affected the safety and quality of life of childbearing-aged women, and its occurrence and development are related to many factors [6]. With the wide application of assisted reproductive technology (ART) in the field of reproduction, it is of great clinical value to identify the risk factors of REP in infertile patients with a history of EP. Multivariate logistic regression was used to analyze the risk factors of REP
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