RISK FACTORS MARKERS OF LUNG CANCER

Abstract

Objective – to evaluate significance of individual markers in the context of diagnosis and prediction of lung cancer course (LC), determination of their role in pathogenetic constructs of the disease. Materials and methods. 115 LC patients aged from 24 to 80 (average age – 58 years old) including 78 % of men and 22 % of women have been examined. None of the patients had been operated for LC previously or had undergone adiochemotherapy before the examination. Small-cell histological variant of the disease was found in 17 % of the patients, non-small cell (adenocarcinoma, squamous cell and large cell-carcinoma) – in 83 %. Levels of transforming b1 and vascular endothelial growth factors, homocysteine, endothelin-1, E and P-selectin, cyclic guanosine monophosphate, fibronectin, C-reactive protein, and a2-macroglobulin were studied in serum. Results. In addition to E-selectin, a significant increase in the concentrations of all values was detected, which was found in 34-100 % of LC cases, and their contents were associated with the form of the disease (central, peripheral), histological variant, integral severity of the tumor process, nature of primary tumor complications (exudative pleurisy, compression syndrome, obstructive atelectasis) and with the peculiarity of metastasis, herewith the values of transforming growth factor b1, vascular endothelial growth factor and fibronectin directly correlate with each other and have a certain unfavorable prognostic significance. Conclusion. The data obtained dictate necessity of studying the concentrations of these markers in the blood of LC patients. It will be useful for assessing the severity of the course of the disease, predicting the complications of its course and selecting the optimal treatment methodology, and also for monitoring the effectiveness of radiochemotherapy.