Abstract
Introduction: Surgical site infection (SSI) is a common postoperative complication and associated with an increased morbidity, hospital stay, and overall cost. The aim of the present study was to identify risk factors for SSIs after hepatic resection based on a large single-center cohort. Methods: A retrospective study was conducted of 6,132 patients who underwent liver resection without concomitant biliary reconstruction or gastrointestinal procedures between 2014 and 2016 at the largest hepatic center in China. The occurrences of SSI, classified as incisional SSI and organ/space SSI within 30 days after operation were investigated. Patient- and surgical-related risk variables were collected using standardized data collection form. A likelihood ratio forward regression model was used to assess the independent association of risk factors with SSI. Results: SSI developed in 587 patients (9.6%), including superficial/deep incisional SSI in 357 patients (5.8 %), and organ/space SSI in 304 patients (5.0 %). Multivariate logistic regression analysis showed that obesity, diabetes mellitus, liver cirrhosis, re-hepatectomy, hepatoliathiasis, and intraoperative blood transfusion were independent risk factors of overall SSI. However, incisional and organ/space SSI differed from each other with respect to risk factors. Among a variety of risk factors, hepatolithiasis, liver cirrhosis, and intraoperative blood transfusion were consistently associated with both incisional and organ/space SSI. Conclusions: SSI is a common complication after liver resection, and more caution should be taken in patients with hepatolithiasis or liver cirrhosis. Prevention strategies focusing on factors associated with SSI is necessary in order to reduce SSI after liver resection.Table[Multivariate Analysis of Risk Factors of Surgical]Odds ratio95% confidence intervalLowHighP valueOverall SSI Obesity (Body mass index > 30)1.621.252.09<0.01 Diabetes mellitus1.431.071.900.03 Cirrhosis1.551.341.80<0.01 Re-hepatectomy1.151.031.31<0.05 Hepatolithiasis1.751.422.13<0.01 Intraoperative blood transfusion1.571.321.98<0.01Incisional SSI Obesity (Body mass index ≥ 30)1.551.301.97<0.01 Diabetes mellitus1.351.181.650.01 Cirrhosis1.611.351.94<0.01 Hypoalbuminemia1.191.031.580.03 Re-hepatectomy1.171.031.32<0.05 Hepatolithiasis1.581.321.99<0.01 Intraoperative blood transfusion1.321.101.680.01Organ/Space SSI Cirrhosis1.701.412.12<0.01 Hepatolithiasis1.661.461.97<0.01 Intra operative blood transfusion1.711.452.11<0.01 Length of abdominal drainage ≥ 5days1.271.071.540.03 Postoperative bile leakage1.221.031.490.04Multivariate Analysis of Risk Factors of Surgical Site Infection after Liver Resection Open table in a new tab Multivariate Analysis of Risk Factors of Surgical Site Infection after Liver Resection
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
