Abstract
Background: SARS-CoV-2 has raged around the world since March, 2020. We aim to describe the clinical characteristics and risk factors of severe patients with COVID-19 in Guangzhou.Results: The severity and mortality of COVID-19 was 10.4% and 0.3% respectively. And each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1.098; P=0.004), Wuhan exposure history greater than 2 weeks (OR, 2.765; 95% CI, 1.040-7.355; P=0.042), diarrhea (OR, 24.349; 95% CI, 3.580-165.609; P=0.001), chronic kidney disease (OR, 6.966; 95% CI, 1.310-37.058; P = 0.023), myoglobin higher than 106 μg/L (OR, 8.910; 95% CI, 1.225-64.816; P=0.031), white blood cell higher than 10×109/L (OR, 5.776; 95% CI, 1.052-31.722; P=0.044), and C-reactive protein higher than 10 mg/L (OR, 5.362; 95% CI, 1.631-17.626; P=0.006) were risk factors for severe cases.Conclusion: Older age, Wuhan exposure history, diarrhea, chronic kidney disease, elevated myoglobin, elevated white blood cell and C-reactive protein were independent risk factors for severe patients with COVID-19 in Guangzhou.Methods: We included 288 adult patients with COVID-19 and compared the data between severe and non-severe group. We used univariate and multivariate logistic regression methods to explore risk factors of severe cases.
Highlights
In December 2019, a large-scale infectious pneumonia of unknown origin broke out in Wuhan, China
The median age of all patients was 48.5 years (IQR 34.3-62), of which women accounted for 54.5% (Table 1). 134 (46.5%) patients had comorbidities, of which cardiovascular disease (CVD) (85, 29.5%) was the most common one, followed by hypertension (84, 29.2%), diabetes (24, 8.3%) (Table 1). 132 patients (45.8%) had a history of exposure to Wuhan 2 weeks before onset (Table 1)
We found that each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1.098; P=0.004), Wuhan exposure history greater than 2 weeks (OR, 2.765; 95% CI, 1.040-7.355; P=0.042), chronic kidney disease (CKD) (OR, 6.966; 95% CI, 1.310-37.058; P = 0.023), diarrhea (OR, 24.349; 95% CI, 3.580-165.609; P=0.001), Myoglobin higher than 106 μg/L (OR, 8.910; 95% CI, 1.225-64.816; P=0.031), white blood cells (WBC) higher than 10×109/L (OR, 5.776; 95% CI, 1.05231.722; P=0.044), and C-reactive protein (CRP) higher than 10 mg/L (OR, 5.362; 95% CI, 1.631-17.626; P=0.006) were independent risk factors for severe cases (Table 4)
Summary
In December 2019, a large-scale infectious pneumonia of unknown origin broke out in Wuhan, China. We aimed to investigate patients with COVID-19 in Guangzhou to find their clinical characteristics and the risk factors for severe cases. Each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1.098; P=0.004), Wuhan exposure history greater than 2 weeks (OR, 2.765; 95% CI, 1.040-7.355; P=0.042), diarrhea (OR, 24.349; 95% CI, 3.580-165.609; P=0.001), chronic kidney disease (OR, 6.966; 95% CI, 1.310-37.058; P = 0.023), myoglobin higher than 106 μg/L (OR, 8.910; 95% CI, 1.225-64.816; P=0.031), white blood cell higher than 10×109/L (OR, 5.776; 95% CI, 1.052-31.722; P=0.044), and C-reactive protein higher than 10 mg/L (OR, 5.362; 95% CI, 1.631-17.626; P=0.006) were risk factors for severe cases. Conclusion: Older age, Wuhan exposure history, diarrhea, chronic kidney disease, elevated myoglobin, elevated white blood cell and C-reactive protein were independent risk factors for severe patients with COVID-19 in Guangzhou. We used univariate and multivariate logistic regression methods to explore risk factors of severe cases
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