Abstract
Gonadotropin-releasing hormone (GnRH) agonists are often used to trigger ovulation during IVF in order to decrease the risk of ovarian hyperstimulation syndrome in high responders. Administration of a GnRH agonist trigger in antagonist cycles causes an endogenous LH surge that promotes follicular maturation prior to oocyte retrieval. Rare instances of failure to mount an appropriate LH surge in response to an agonist trigger have been reported, an event associated with decreased oocyte maturity, low oocyte yield, and compromised cycle outcomes.
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