Risk factors and homology of bloodstream infection in Burkholderia cepacia

Abstract

Objective To investigate the risk factors and homology of bloodstream infection (BSI) in Burkholderia cepacia. Methods The Burkholderia cepacia isolated from patients with bloodstream infection in Shaoxing People’s Hospital from January 2014 to December 2016 were collected and analyzed by pulsed field gel electrophoresis (PFGE). The clinical data of BSI patients with Burkholderia cepacia were analyzed, patients with non-Burkholderia cepacia blood BSI were collected as control group. The risk factors of BSI in Burkholderia cepacia were investigated, and survival or not was taken as a prognostic criterion for Burkholderia cepacia of strain BSI, Logistic regression analysis of single factor and multi-factors were carried out, and the influencing factors of survival were analyzed. Results Total of 32 strains of Burkholderia cepacia were divided into 7 clones, named as cloned A (15 strains), cloned B (8 strains), cloned C (3 strains), cloned D and cloned E (each of the 2 strains), cloned F and cloned G (each of the 1 strains). Twelve patients died of BSI of Burkholderia cepacia, the mortality rate was 37.5%. There were 77 cases of non-Burkholderia cepacia in patients with BSI, multiple Logistic regression analysis showed that age, hospitalization of ICU longer than two weeks, APACHE Ⅱ score and strain of efflux pump gene were all independent risk factors for BSI of Burkholderia cepacia (OR = 8.835, 6.353, 6.679 and 5.606, all P < 0.05). Conclusions The infection of Burkholderia cepacia in ICU ward was popular. Age, hospitalization period of ICU longer than two weeks, APACHE Ⅱ score and the presence of efflux pump gene were more likely to cause BSI Burkholderia cepacia in patients. Key words: Burkholderia cepacia; Infection; Risk factor; Homology