Abstract
Abstract magnified imageAn approach to pyrano[2,3‐c]pyrazoles starting from spirocyclopropanepyrazoles via a ring‐opening/cyanomethylation and intramolecular cyclization is described. Reactions of spirocyclopropanepyrazoles 1a, 1b, 1c, 1d with chloroacetonitrile in the presence of sodium hydride gave the corresponding cyanomethoxypyrazoles 4a, 4b, 4c, 4d. Treatment of 4a, 4b, 4c, 4d with sodium hydride at room temperature caused intramolecular Michael addition reaction to afford the corresponding pyrano[2,3‐c]pyrazoles 5a, 5b, 5c, 5d. J. Heterocyclic Chem., (2009).
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