Abstract
Right atrial thrombi may develop within the right atrium or may have peripheral venous origins that, on their way to the final destination site lodge in, right atrium. Right atrial thrombosis is classified as two type: A (mobile, thin) and B (non mobile and attached to atrial wall) that they are probably of cardiac origin due to local pathology, indwelling catheter, atrial fibrillation, stasis, rheumatological or hematological disease like protein C or S deficiency. Protein C deficiency has been reported to be a risk factor for thrombosis in multiple organs as a result of inactivation of factor of Va. We describe a case of a huge right atrial thrombus with cerebral sagittal sinus thrombosis, in a protein C-S deficient patient, in which right atrial clot was successfully removed surgically and sagittal vein treated conservatively with full recovery of his central neurologic symptom. Magnetic Resonance Imaging demonstrated thrombosis in those regions.
Highlights
Protein C-S deficiency is genetic traits predisposing to the formation of thrombosis in venous system.[1]
Brain C-T scan and MRI revealed sagittal venous system thrombosis (Figure 2). This is the first reported case of right atrial thrombosis associated with protein C-S deficiency and sagittal sinus thrombosis
The hereditary protein C-S deficiency is a group of inherited conditions that predispose to thrombosis
Summary
Protein C-S deficiency is genetic traits predisposing to the formation of thrombosis in venous system.[1]. Sagittal sinus thrombosis can be caused by a wide range of etiologies, including hypercoagulable disorders, such as factor V Leiden mutation, presence of anticardiolipin antibody, antithrombin gene mutation, polycythemia and protein C-S deficiency and hypercysteinemia.[2] This report a protein C-S deficient patient who had concomitant a right atrial giant thrombus with sagittal sinus thrombosis.
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